Human Laboratory Research to Inform Precision Regulation of E-cigarettes Across Populations Project 4

Project 4 will identify dimensions of e-cigarette product diversity that put young adult never-smokers at risk of using e-cigarettes, yet do not deter middle/older adult smokers from adopting and potentially switching to e-cigarettes. In two studies, subjects will self-administer e-cigarette products varied according to three dimensions: flavor (e.g., sweet vs. menthol vs. tobacco); propylene glycol/vegetable glycerin ratio (e.g., 20:80 vs. 40:60 vs. 60:40 vs. 80:20); and packaging design (e-liquid characterizing flavor label [e.g., “peach”] vs. youth-oriented non-characterizing flavor [e.g., “gummy heaven”] vs. non-characterizing flavor + cartoon).

 

Principal Investigator

Adam Leventhal, Ph.D.
Professor of Preventive Medicine
Director of Health, Emotion, & Addiction Laboratory


Project Aims

Aim 1: To determine which dimensions of e-cigarette product diversity differentially affect product appeal in never-smoking young adult e-cigarette users and middle-aged/older adult smokers with an interest in, but no significant experience with, e-cigarettes

Aim 2: To determine which dimensions of e-cigarette product diversity differentially affect abuse liability in never-smoking young adult e-cigarette users and ability to resist smoking in middle-aged/older adult smokers with an interest in, but no significant experience with, e-cigarettes

Aim 3: To examine sex differences in the effects of product diversity on appeal, abuse liability, and ability to resist smoking by testing sex and product dimension interactions

For more information on this project, please contact tcors@usc.edu

Publications

The University of Southern California's Tobacco Center of Regulatory Science (USC TCORS) for Vulnerable Populations is one of 9 Tobacco Centers of Regulatory Science in the U.S. We were created to serve in the production of relevant scientific data to inform the regulatory decision making at the Food and Drug Administration's (FDA) Center for Tobacco Products. Additionally, we are here to educate and train the next generation of tobacco regulatory scientists.

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