Rapid Response Projects

Current Projects


Evaluation of the Value of Varying E-cigarette Product Characteristics Across Different Populations: A conjoint analysis of 6 product characteristics among youth and young adults

PI: Jessica Barrington- Trimis, Ph.D.

Aim 1: To characterize the relative importance and price utility of product attributes (flavor, packaging, nicotine formulation, warning label size, device type, price) and levels within each attribute among participants with any history of e-cigarette use or use of another tobacco product.

Aim 2: To evaluate whether outcomes described in Aim 1 differ between youth nonsmokers and young adult smokers. Secondary analyses will evaluate whether outcomes also differ by race/ethnicity, LGBTQ+ status, gender, frequency of e-cigarette use, history of other tobacco use, and nicotine dependence, to provide evidence regarding the impact of such features on vulnerable populations with a disproportionate share of the tobacco related disease burden.

Adverse Outcomes Associated with E-cigarette Device Type Among Youth and Young Adults: A Pooled Analysis Across 3 Tobacco Centers of Regulatory Science

PI: Jessica Barrington- Trimis, Ph.D.

Aim 1: To evaluate the association of e-cigarette device type with symptoms of nicotine dependence using combined cross-sectional data from all three centers.

Aim 2: To evaluate the association of e-cigarette device type with progression to more frequent e-cigarette use and with initiation of other tobacco product use (including dual/polytobacco product use) using combined prospective data.

Aim 3: To evaluate the association of e-cigarette device type (vape pen vs. mod vs. JUUL or other pod products) with adverse respiratory health symptoms (e.g., symptoms of asthma or bronchitis) using combined cross-sectional data.


Evaluating the Influence of Local Flavored E-cigarette Sales Restrictions on E-cigarette and Other Tobacco Use Outcomes Among Vulnerable Populations

PI: Julia Chen-Sankey, Ph.D.

Aim 1. To examine the influence of FESRs on e-cigarette use.

Aim 2. To examine the influence of FESRs on other tobacco use and tobacco purchasing location.

Aim 3. To examine the influence of FESRs among the historically targeted vulnerable populations.

Examining Risk Beliefs and IQOS Use Among Adults

PI: Alayna Tackett, Ph.D.

Aim 1: To assess the effect of provision of IQOS on substitution and/or co-use of usual brand cigarettes. Descriptive analyses of IQOS use over the 1-month observation period will be performed.

Aim 2: To evaluate shifts in product perceptions associated with switching from usual cigarettes to IQOS.

Aim 3: To examine the acute changes via EMA/mobile spirometry in pulmonary functioning upon switching from combustible cigarettes to IQOS during the 1-month monitoring period.


Effects of Ice Flavors and Nicotine on E-Cigarette Product Appeal and Likelihood of Future Use in Adults

PI: Adam Leventhal, Ph.D.

Aim 1. To test the hypothesis that there will be a main effect of flavor on appeal and intention to use outcome ratings, such that mean ratings will be greater for ice vs. plain flavor variants.  

Aim 2. To test the hypothesis that there will be an interaction between ice flavor status and nicotine concentration, such that the aversive appeal- and intention-reducing qualities of 4% vs. 2% products will be suppressed when combined with ice vs. plain flavor variants. 

Secondary aim.  To determine whether tobacco product user status (e.g., ever vs. never regular smoker of combustible cigarettes [based on > 100 vs < 100 cigarettes lifetime) moderates the flavor and flavor x nicotine concentration effects hypothesized in Aims 1-2.

The University of Southern California's Tobacco Center of Regulatory Science (USC TCORS) for Vulnerable Populations is one of 9 Tobacco Centers of Regulatory Science in the U.S. We were created to serve in the production of relevant scientific data to inform the regulatory decision making at the Food and Drug Administration's (FDA) Center for Tobacco Products. Additionally, we are here to educate and train the next generation of tobacco regulatory scientists.

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