Dr. Mary Ann Pentz is Director of the Institute for Health Promotion and Disease Prevention Research (IPR), Director of the Division of Health Behavior Research in Preventive Medicine, and co-Director of the Cancer Control Program of the Norris Comprehensive Cancer Center. All of her research and leadership experience over the last 25 years has focused on prevention of chronic diseases of lifestyle, with a primary emphasis on adolescents and their families. Her prevention research has focused on developing and evaluating interventions to prevent the multiple health risk and disseminating both programmatic and policy interventions for tobacco and alcohol use, physical activity, sedentary behavior, nutrition, obesity, stress, and sleep in large randomized trials that involve communities, schools, and families, for all of which she has been PI. As PI of the NIH Tobacco Center of Regulatory Science (TCORS, with Jon Samet), her TCORS research has developed and disseminated evidence-based tobacco prevention strategies and promoted adoption of evidence-based prevention policies. Dr. Pentz has also organized and coordinated large teams of transdisciplinary researchers and resources required for large-scale trials.